Well: Boosting Your Flu Shot Response

Phys Ed

Gretchen Reynolds on the science of fitness.

As this year’s influenza season continues to take its toll, those procrastinators now hurrying to get a flu shot might wish to know that exercise may amplify the flu vaccine’s effect. And for maximal potency, the exercise should be undertaken at the right time and involve the right dosage of sweat, according to several recent reports.

Flu shots are one of the best ways to lessen the risk of catching the disease. But they are not foolproof. By most estimates, the yearly flu vaccine blocks infection 50 to 70 percent of the time, meaning that some of those being inoculated gain little protection. The more antibodies someone develops, the better their protection against the flu, generally speaking. But for some reason, some people’s immune systems produce fewer antibodies to the influenza virus than others’ do.

Being physically fit has been found in many studies to improve immunity in general and vaccine response in particular. In one notable 2009 experiment, sedentary, elderly adults, a group whose immune systems typically respond weakly to the flu vaccine, began programs of either brisk walking or a balance and stretching routine. After 10 months, the walkers had significantly improved their aerobic fitness and, after receiving flu shots, displayed higher average influenza antibody counts 20 weeks after a flu vaccine than the group who had stretched.

But that experiment involved almost a year of dedicated exercise training, a prospect that is daunting to some people and, in practical terms, not helpful for those who have entered this flu season unfit.

So scientists have begun to wonder whether a single, well-calibrated bout of exercise might similarly strengthen the vaccine’s potency.

To find out, researchers at Iowa State University in Ames recently had young, healthy volunteers, most of them college students, head out for a moderately paced 90-minute jog or bike ride 15 minutes after receiving their flu shot. Other volunteers sat quietly for 90 minutes after their shot. Then the researchers checked for blood levels of influenza antibodies a month later.

Those volunteers who had exercised after being inoculated, it turned out, exhibited “nearly double the antibody response” of the sedentary group, said Marian Kohut, a professor of kinesiology at Iowa State who oversaw the study, which is being prepared for publication. They also had higher blood levels of certain immune system cells that help the body fight off infection.

To test how much exercise really is required, Dr. Kohut and Justus Hallam, a graduate student in her lab, subsequently repeated the study with lab mice. Some of the mice exercised for 90 minutes on a running wheel, while others ran for either half as much time (45 minutes) or twice as much (3 hours) after receiving a flu shot.

Four weeks later, those animals that, like the students, had exercised moderately for 90 minutes displayed the most robust antibody response. The animals that had run for three hours had fewer antibodies; presumably, exercising for too long can dampen the immune response. Interestingly, those that had run for 45 minutes also had a less robust response. “The 90-minute time point appears to be optimal,” Dr. Kohut says.

Unless, that is, you work out before you are inoculated, another set of studies intimates, and use a dumbbell. In those studies, undertaken at the University of Birmingham in England, healthy, adult volunteers lifted weights for 20 minutes several hours before they were scheduled to receive a flu shot, focusing on the arm that would be injected. Specifically, they completed multiple sets of biceps curls and side arm raises, employing a weight that was 85 percent of the maximum they could lift once. Another group did not exercise before their shot.

After four weeks, the researchers checked for influenza antibodies. They found that those who had exercised before the shot generally displayed higher antibody levels, although the effect was muted among the men, who, as a group, had responded to that year’s flu vaccine more robustly than the women had.

Over all, “we think that exercise can help vaccine response by activating parts of the immune system,” said Kate Edwards, now a lecturer at the University of Sydney, and co-author of the weight-training study.

With the biceps curls, she continued, the exercises probably induced inflammation in the arm muscles, which may have primed the immune response there.

As for 90 minutes of jogging or cycling after the shot, it probably sped blood circulation and pumped the vaccine away from the injection site and to other parts of the body, Dr. Kohut said. The exercise probably also goosed the body’s overall immune system, she said, which, in turn, helped exaggerate the vaccine’s effect.

But, she cautions, data about exercise and flu vaccines is incomplete. It is not clear, for instance, whether there is any advantage to exercising before the shot instead of afterward, or vice versa; or whether doing both might provoke the greatest response – or, alternatively, be too much and weaken response.

So for now, she says, the best course of action is to get a flu shot, since any degree of protection is better than none, and, if you can, also schedule a visit to the gym that same day. If nothing else, spending 90 minutes on a stationary bike will make any small twinges in your arm from the shot itself seem pretty insignificant.

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Well: Boosting Your Flu Shot Response

Phys Ed

Gretchen Reynolds on the science of fitness.

As this year’s influenza season continues to take its toll, those procrastinators now hurrying to get a flu shot might wish to know that exercise may amplify the flu vaccine’s effect. And for maximal potency, the exercise should be undertaken at the right time and involve the right dosage of sweat, according to several recent reports.

Flu shots are one of the best ways to lessen the risk of catching the disease. But they are not foolproof. By most estimates, the yearly flu vaccine blocks infection 50 to 70 percent of the time, meaning that some of those being inoculated gain little protection. The more antibodies someone develops, the better their protection against the flu, generally speaking. But for some reason, some people’s immune systems produce fewer antibodies to the influenza virus than others’ do.

Being physically fit has been found in many studies to improve immunity in general and vaccine response in particular. In one notable 2009 experiment, sedentary, elderly adults, a group whose immune systems typically respond weakly to the flu vaccine, began programs of either brisk walking or a balance and stretching routine. After 10 months, the walkers had significantly improved their aerobic fitness and, after receiving flu shots, displayed higher average influenza antibody counts 20 weeks after a flu vaccine than the group who had stretched.

But that experiment involved almost a year of dedicated exercise training, a prospect that is daunting to some people and, in practical terms, not helpful for those who have entered this flu season unfit.

So scientists have begun to wonder whether a single, well-calibrated bout of exercise might similarly strengthen the vaccine’s potency.

To find out, researchers at Iowa State University in Ames recently had young, healthy volunteers, most of them college students, head out for a moderately paced 90-minute jog or bike ride 15 minutes after receiving their flu shot. Other volunteers sat quietly for 90 minutes after their shot. Then the researchers checked for blood levels of influenza antibodies a month later.

Those volunteers who had exercised after being inoculated, it turned out, exhibited “nearly double the antibody response” of the sedentary group, said Marian Kohut, a professor of kinesiology at Iowa State who oversaw the study, which is being prepared for publication. They also had higher blood levels of certain immune system cells that help the body fight off infection.

To test how much exercise really is required, Dr. Kohut and Justus Hallam, a graduate student in her lab, subsequently repeated the study with lab mice. Some of the mice exercised for 90 minutes on a running wheel, while others ran for either half as much time (45 minutes) or twice as much (3 hours) after receiving a flu shot.

Four weeks later, those animals that, like the students, had exercised moderately for 90 minutes displayed the most robust antibody response. The animals that had run for three hours had fewer antibodies; presumably, exercising for too long can dampen the immune response. Interestingly, those that had run for 45 minutes also had a less robust response. “The 90-minute time point appears to be optimal,” Dr. Kohut says.

Unless, that is, you work out before you are inoculated, another set of studies intimates, and use a dumbbell. In those studies, undertaken at the University of Birmingham in England, healthy, adult volunteers lifted weights for 20 minutes several hours before they were scheduled to receive a flu shot, focusing on the arm that would be injected. Specifically, they completed multiple sets of biceps curls and side arm raises, employing a weight that was 85 percent of the maximum they could lift once. Another group did not exercise before their shot.

After four weeks, the researchers checked for influenza antibodies. They found that those who had exercised before the shot generally displayed higher antibody levels, although the effect was muted among the men, who, as a group, had responded to that year’s flu vaccine more robustly than the women had.

Over all, “we think that exercise can help vaccine response by activating parts of the immune system,” said Kate Edwards, now a lecturer at the University of Sydney, and co-author of the weight-training study.

With the biceps curls, she continued, the exercises probably induced inflammation in the arm muscles, which may have primed the immune response there.

As for 90 minutes of jogging or cycling after the shot, it probably sped blood circulation and pumped the vaccine away from the injection site and to other parts of the body, Dr. Kohut said. The exercise probably also goosed the body’s overall immune system, she said, which, in turn, helped exaggerate the vaccine’s effect.

But, she cautions, data about exercise and flu vaccines is incomplete. It is not clear, for instance, whether there is any advantage to exercising before the shot instead of afterward, or vice versa; or whether doing both might provoke the greatest response – or, alternatively, be too much and weaken response.

So for now, she says, the best course of action is to get a flu shot, since any degree of protection is better than none, and, if you can, also schedule a visit to the gym that same day. If nothing else, spending 90 minutes on a stationary bike will make any small twinges in your arm from the shot itself seem pretty insignificant.

Read More..

Rights Group Reports on Abuses of Surveillance and Censorship Technology

A Canadian human rights monitoring group has documented the use of American-made Internet surveillance and censorship technology by more than a dozen governments, some with harsh human rights policies like Syria, China and Saudi Arabia.

Jakub Dalek of the Munk School of Global Affairs.

Thor Swift for The New York Times

Morgan Marquis-Boire led the research with Mr. Dalek.

The Citizen Lab Internet research group, based at the Munk School of Global Affairs at the University of Toronto, used computer servers to scan for the distinctive signature of gear made by Blue Coat Systems of Sunnyvale, Calif.

It determined that Egypt, Kuwait, Qatar, Saudi Arabia and the United Arab Republic employed a Blue Coat system that could be used for digital censorship. The group also determined that Bahrain, China, India, Indonesia, Iraq, Kenya, Kuwait, Lebanon, Malaysia, Nigeria, Qatar, Russia, Saudi Arabia, South Korea, Singapore, Thailand, Turkey and Venezuela used equipment that could be used for surveillance and tracking.

The authors said they wanted to alert the public that there was a growing amount of surveillance and content-filtering technology distributed throughout the Internet. The technology is not restricted from export by the State Department, except to countries that are on embargo lists, like Syria, Iran and North Korea.

“Our findings support the need for national and international scrutiny of the country Blue Coat implementations we have identified, and a closer look at the global proliferation of dual-use information and communications technology,” the group noted. “We hope Blue Coat will take this as an opportunity to explain their due diligence process to ensure that their devices are not used in ways that violate human rights.”

A spokesman for Blue Coat Systems said the firm had not seen the final report and was not prepared to comment.

In 2011, several groups, including Telecomix and Citizen Labs, raised concerns that Blue Coat products were being used to find and track opponents of the Syrian government. The company initially denied that its equipment had been sold to Syria, which is subject to United States trade sanctions.

Shortly afterward, Blue Coat reversed itself and acknowledged that the systems were indeed in Syria, but it said that the devices had been shipped to a distributor in Dubai, and said that it thought that they had been destined for the Iraqi Ministry of Communications.

The Citizen Lab research project was led by Morgan Marquis-Boire and Jakub Dalek. Mr. Marquis-Boire, a Google software engineer, has during the last year been involved in a variety of research projects aimed at exposing surveillance tools used by authoritarian regimes. He said that he carefully segregated his work at Google from his human rights research.

Last year, Mr. Marquis-Boire used computer servers to identify the use of an intelligence-oriented surveillance software program, called FinSpy, which was being used by Bahrain to track opposition activists.

On a hunch last month, the researchers used the Shodan search engine, a specialized Internet tool intended to help identify computers and software services that were connected to the Internet. They were able to identify a number of the Blue Coat systems that are used for content filtering and for “deep packet inspection,” a widely used technology for detecting and controlling digital content as it travels through the Internet.

The researchers stressed that they were aware that there were both benign and harmful uses for the Blue Coat products identified as ProxySG, which functions as a Web filter, and a second system, PacketShaper, which can detect about 600 Web applications and can be used to control undesirable Web traffic.

“I’m not trying to completely demonize this technology,” Mr. Marquis-Boire said.

The researchers also noted that the equipment does not directly fall under the dual-use distinction employed by the United States government to control the sale of equipment that has both military and civilian applications, but it can be used for both political and intelligence applications by authoritarian governments.

“Syria is subject to U.S. export sanctions,” said Sarah McCune, a senior researcher at the Citizen Lab. “When it comes to other countries that aren’t subject to U.S. sanctions it’s a more difficult situation. There could still be significant human rights impact.”

The researchers also noted that a large number of American and foreign companies supplied similar gear in what Gartner, the market research firm, described as a $1.02 billion market in a report issued in May 2012.

The researchers said that some American security technology companies, like Websense, had taken strong human rights stands, but had declined to grapple with the issue of the possible misuse of the technology.

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Dreamliner Jet Makes Emergency Landing in Japan Due to Battery

TOKYO (AP) — Boeing Co.'s 787 planes were grounded for safety checks Wednesday by two major Japanese airlines after one was forced to make an emergency landing in the latest blow for the new jet.

All Nippon Airways said a cockpit message showed battery problems and a burning smell was detected in the cockpit and the cabin, forcing the 787 on a domestic flight to land at Takamatsu airport in western Japan.

The 787, known as the Dreamliner, is Boeing's newest and most technologically advanced jet, and the company is counting heavily on its success. Since its launch, which came after delays of more than three years, the plane has been plagued by a series of problems including a battery fire and fuel leaks. Japan's ANA and Japan Airlines are major customers for the jet and among the first to fly it.

Japan's transport ministry said it got notices from ANA, which operates 17 of the jets, and Japan Airlines which has seven, that all their 787 aircraft would not be flying. The grounding was done voluntarily by the airlines.

The ministry categorized the problem Wednesday as a "serious incident" that could have led to an accident, and sent officials for further checks to Takamatsu airport. The airport was closed.

ANA executives apologized, bowing deeply at a hastily called news conference in Tokyo.

"We are very sorry to have caused passengers and their family members so much concern," said ANA Senior Executive Vice President Osamu Shinobe.

One male in his 60s was taken to the hospital for minor hip injuries after going down the emergency slides at the airport, the fire department said. The other 128 passengers and eight crew members of the ANA domestic flight were uninjured, according to ANA.

The grounding in Japan was the first for the 787, whose problems had been brushed off by Boeing as teething pains for a new aircraft. The ministry had already started a separate inspection Monday on another 787 jet, operated by Japan Airlines, which had leaked fuel at Tokyo's Narita airport after flying back from Boston, where it had also leaked fuel.

A fire ignited Jan. 7 in the battery pack of an auxiliary power unit of a Japan Airlines 787 empty of passengers as the plane sat on the tarmac at Boston's Logan International Airport. It took firefighters 40 minutes to put out the blaze.

ANA cancelled a domestic flight to Tokyo on Jan. 9 after a computer wrongly indicated there was a problem with the Boeing 787's brakes. Two days later, the carrier reported two new cases of problems with the aircraft, a minor fuel leak and a cracked windscreen in a 787 cockpit.

The 787 relies more than any other modern airliner on electrical signals to help power nearly everything the plane does. It's also the first Boeing plane to use rechargeable lithium ion batteries, which charge faster and can be molded to space-saving shapes compared to other airplane batteries. The plane is made with lightweight composite materials instead of aluminum.

The U.S. Federal Aviation Administration said in a statement that it is "monitoring a preliminary report of an incident in Japan earlier today involving a Boeing 787."

It said the incident will be included in the comprehensive review the FAA began last week of the 787 critical systems, including design, manufacture and assembly. U.S. government officials were quick to say that the plane is safe — nearly 50 of them are in the skies now.

GS Yuasa Corp., the Japanese company that supplies all the lithium ion batteries for the 787, had no comment as the investigation was still ongoing.

In Tokyo, the transport minister, Akihiro Ota, said authorities were taking the incidents seriously.

"These problems must be fully investigated," he said.

Boeing has said that various technical problems are to be expected in the early days of any aircraft model.

"Boeing is aware of the diversion of a 787 operated by ANA to Takamatsu in western Japan. We will be working with our customer and the appropriate regulatory agencies," Boeing spokesman Marc Birtel said.

In Wednesday's incident, a cockpit instrument showed a problem with the 787's battery and the pilot noticed an unusual smell, the airline said. The flight requested and was granted permission to make an emergency landing at Takamatsu airport.

Aviation safety expert John Goglia, a former National Transportation Safety Board member, said the ANA pilot had made the right choice.

"They were being very prudent in making the emergency landing even though there's been no information released so far that indicates any of these issues are related," he said.

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DealBook: The Banker Who Put His Faith in Armstrong

When Lance Armstrong’s interview with Oprah Winfrey about his suspected use of illegal performance-enhancing drugs is broadcast on Thursday, an investment banker will most likely be watching it very carefully (and nervously): Thomas Weisel.

Mr. Weisel is a legend in finance and Silicon Valley. He was the banker behind Yahoo’s public offering and some of the biggest deals during the dot-com bubble. He famously sold the firm he ran, Montgomery Securities, for $1.2 billion in 1997. And he sold his next firm, Thomas Weisel Partners, for $300 million to Stifel Financial in 2010.

But it is Mr. Weisel’s extracurricular activity that connects him to the news of the moment: he was Mr. Armstrong’s biggest financial backer and the single individual most responsible for the money machine that propelled Mr. Armstrong’s career.

Depending on what Mr. Armstrong says in the interview about his purported doping, Mr. Weisel, who was a co-owner of the United States Postal Service Pro Cycling Team through a cycling management firm that he helped found called Tailwind Sports, could be subject along with his partners to lawsuits from corporate sponsors seeking millions of dollars. Already, there is a False Claims Act case contending that Mr. Armstrong and the team defrauded the Postal Service.

Perhaps more anxiety-producing is what Mr. Weisel may have known, or should have known, about a team that for years ran “the most sophisticated, professionalized and successful doping program that sport has ever seen,” according to the United States Anti-Doping Agency.

Its report last year did not name Mr. Weisel, but did say that Mr. Armstrong was assisted by a “small army of enablers, including doping doctors, drug smugglers, and others within and outside the sport and on his team.”

Mr. Armstrong is expected to admit to doping in an effort to persuade officials to lift his lifetime ban from Olympic sports. To do so, however, he would probably need to lay out in explicit detail how the program worked and implicate those who were part of it. Late Monday, The New York Times reported that Mr. Armstrong had confessed in the interview with Ms. Winfrey that he used performance-enhancing drugs. The Times also reported that he was in discussions with the Justice Department to possibly testify in a federal whistle-blower case against several team officials and owners, including Mr. Weisel.

Mr. Weisel is currently not talking. When I called Mr. Weisel seeking a comment, his assistant told me: “He’s not commenting. And he’s not returning any calls.”

For a glimpse of the way Mr. Weisel thinks about performance-enhancing drugs in cycling, here’s what he had to say about the matter four years ago: “Handle the problem below the surface and keep the image of the sport clean,” he told The Wall Street Journal. “In the U.S. sports — baseball, basketball, football — most fans couldn’t care less.”

For Mr. Weisel, the team and Mr. Armstrong were an all-consuming passion. He would go every year to the Tour de France and at times travel in the team’s pacer car, occasionally yelling instructions to Mr. Armstrong over the radio system. He rode the team’s bus, ate meals with them and ultimately celebrated each year’s victory. On the wall of his office in San Francisco, he displayed Mr. Armstrong’s yellow jerseys.

Always the consummate banker, Mr. Weisel even tried to help Mr. Armstrong raise funds to buy the Tour de France itself. (The effort never went anywhere.)

Mr. Weisel’s name has occasionally come up in connection with accusations of doping on the team.

The wife of the famed cyclist Greg LeMond, Kathy, reportedly testified under oath in a deposition in 2006 that she had been told by one of Mr. Armstrong’s mechanics that Mr. Weisel, along with Nike, paid $500,000 though a Swiss bank account to the honorary president of the International Cycling Union to silence a drug test Mr. Armstrong purportedly failed in 1999.

Nike has vehemently denied the contention. So far, Mr. Weisel has not commented publicly.

When Floyd Landis, one of Mr. Armstrong’s former teammates, tested positive in 2006, he denied using performance-enhancing drugs under pressure from Mr. Armstrong. Soon after, Mr. Weisel set up the Floyd Fairness Fund with some of Tailwind’s co-owners to help pay his legal bills. Mr. Landis later confessed to doping in 2010.

Mr. Weisel, a longtime athlete who was a champion speed skater as a teenager, became a cycling enthusiast in the 1980s and took up racing himself. Sports dominated his life: he often said that he liked to hire athletes to work for him at the bank because of their competitive instincts. He was also the chairman of the United States Ski Team Foundation. In 1987, while still working as a banker, he started Montgomery Sports, to begin his first cycling team. In the early 1990s the team was called Subaru-Montgomery; it later became Montgomery-Bell (Bell Sports was a client that he took public) and then was renamed for the Postal Service. (Yahoo, another client, was also a sponsor of the team.)

According to a biography of Mr. Weisel, “Capital Instincts: Life as an Entrepreneur, Financier and Athlete,” he invested more than $5 million in the early teams and lost money on the investment. Mr. Armstrong was one of Mr. Weisel’s early riders for the Subaru-Montgomery team. He later left the team to join the Motorola team. After his bout with cancer, Mr. Armstrong joined what was the Postal Service team in 1998.

Tyler Hamilton, another former teammate of Mr. Armstrong, told “60 Minutes” that the team was pushing performance-enhancing drugs on its cyclists long before Mr. Armstrong battled cancer and then in 1998 rejoined the team.

“I remember seeing some of the stronger guys in the team getting handed these white lunch bags,” Mr. Hamilton said on “60 Minutes” about when he joined the team in 1995. “So finally I, you know, started puttin’ two and two together and you know, basically there were doping products in those white lunch bags.”

Given how widespread the doping now appears to have been on the Postal Service team based on testimony of 11 teammates, and charges against the team’s director and several of its doctors, you wonder how much due diligence its founding banker did on the most prominent deal of his career.

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Well: Turning to the Web for a Medical Diagnosis

Thirty-five percent of American adults said they have used the Internet to diagnose a medical condition for themselves or someone else, according to a new Pew Research Center study. Women are more likely than men to turn to the Internet for diagnoses. Other groups more likely to do so are younger people, white adults, people with college degrees and those who live in households with income above $75,000.

The study, released by Pew’s Internet and American Life Project on Tuesday, points out that Americans have always tried to answer their health questions at home, but that the Internet has expanded the options for research. Previous surveys have asked questions about online diagnoses, but the Pew study was the first to focus on the topic with a nationally representative sample, said Susannah Fox, an associate director at Pew Internet. Surveyors interviewed 3,014 American adults by telephone, from August to September 2012.

Of the one in three Americans who used the Internet for a diagnosis, about a third said they did not go to a doctor to get a professional medical opinion, while 41 percent said a doctor confirmed their diagnosis. Eighteen percent said a doctor did not agree with their diagnosis. As far as where people start when researching health conditions online, 77 percent said they started at a search engine like Google, Bing or Yahoo, while 13 percent said they began at a site that specializes in health information.

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Well: Turning to the Web for a Medical Diagnosis

Thirty-five percent of American adults said they have used the Internet to diagnose a medical condition for themselves or someone else, according to a new Pew Research Center study. Women are more likely than men to turn to the Internet for diagnoses. Other groups more likely to do so are younger people, white adults, people with college degrees and those who live in households with income above $75,000.

The study, released by Pew’s Internet and American Life Project on Tuesday, points out that Americans have always tried to answer their health questions at home, but that the Internet has expanded the options for research. Previous surveys have asked questions about online diagnoses, but the Pew study was the first to focus on the topic with a nationally representative sample, said Susannah Fox, an associate director at Pew Internet. Surveyors interviewed 3,014 American adults by telephone, from August to September 2012.

Of the one in three Americans who used the Internet for a diagnosis, about a third said they did not go to a doctor to get a professional medical opinion, while 41 percent said a doctor confirmed their diagnosis. Eighteen percent said a doctor did not agree with their diagnosis. As far as where people start when researching health conditions online, 77 percent said they started at a search engine like Google, Bing or Yahoo, while 13 percent said they began at a site that specializes in health information.

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California to Give Web Courses a Big Trial

A plan to offer an array of online college classes at a California state university could, if the students are successful, open the door to teaching hundreds of thousands of California students at a lower cost via the Internet.

Udacity, a Silicon Valley start-up that creates online college classes, will announce a deal on Tuesday with San Jose State University for a series of remedial and introductory courses.

Because the courses are intended to involve the classroom instructor, it could also help to blunt professors’ unease with the online classes. 

The state university’s deal with Udacity is also the first time that professors at a university have collaborated with a provider of a MOOC — massively open online course — to create courses with students first watching videos on their own, with support from online mentors, and then coming to class to work on assignments with a professor.

Eventually, such blended courses could be offered to hundreds of thousands of students in the state.

California Gov. Jerry Brown, who has been pushing state universities to move more aggressively into online education, approached the company to come up with a technological solution for what has become a vexing challenge for the state.

Ellen N. Junn, provost and vice president for academic affairs at the university in San Jose, said the California State University System faces a crisis because more than 50 percent of entering students cannot meet basic requirements.

“They graduate from high school, but they cannot pass our elementary math and English placement tests,” she said.

The Udacity pilot program will include a remedial algebra course, a college-level algebra course and introductory statistics.

For the pilot project starting this month, however, the courses will be limited to 300 students — half from San Jose State University, and half from local community colleges and high schools — who will pay lower than usual tuition. The cost of each three-unit course will be $150, significantly less than regular San Jose State tuition. Sebastian Thrun, one of the founders of Udacity, would not disclose how much the company would be paid for its participation.

San Jose State will receive funds from the National Science Foundation to study the effectiveness of the new online classroom design.

Open online courses exploded in American higher education in 2011 after Mr. Thrun, a nationally known artificial-intelligence researcher at Stanford, and Peter Norvig, Google’s director of research, offered to teach an introductory artificial-intelligence course online. More than 160,000 students initially registered for the class.

After two other Stanford courses each attracted more than 100,000 students, Dr. Thrun started his venture. Two other Stanford computer scientists, Andrew Ng and Daphne Koller, also established a competing private company, Coursera, to develop technologies necessary to change the reach and effectiveness of online education.

The courses have rapidly moved from the periphery to the center of higher education policy as a growing number of schools have begun experimenting with ways to offer the courses for credit toward a degree.

EdX, a university collaboration initiated by the Massachusetts Institute of Technology and Harvard last year, this month will begin offering some of its courses at two Massachusetts community colleges, also in a blended format.

Recently edX completed a pilot offering of its difficult circuits and electronics course at San Jose State to stunning results: while 40 percent of the students in the traditional version of the class got a grade of C or lower, only 9 percent in the blended edX class got such a low grade.

Last fall, for the first time, Udacity’s courses were tried on a small group of struggling high school students, at the Winfree Academy Charter School system, a cluster of schools near Dallas-Fort Worth created to help struggling students and reclaim dropouts.

“I was a little scared to put our kids, who are struggling and at risk of dropping out, into a class written by a Stanford professor,” said Melody Chalkley, Winfree’s founder. “But of the 23 students who used Udacity, one withdrew from the school, and the other 22 all finished successfully. And two young women got through the whole physics course in just two weeks.”

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At War Blog: Russian Military Ordered to Switch Portyanki for Socks

Near the end of World War II, Soviet and American soldiers met at the Elbe River in Germany. Lacking a common language, they compared their boots.

The Americans wore socks and lace-up boots. The Russians wore something that boggled the minds of their allies from the West: pieces of cloth twirled around their feet and inserted into bulky, knee-high boots.

The cloth strips, called portyanki, have been a signature element of the Russian military uniform since the 16th century. On Monday Russia’s minister of defense issued an order for a militarywide switch to socks.

“I have an instruction for you,” the minister, Sergei K. Shoigu, said to a gathering of the equivalent of the chiefs of staff and regional commanders in comments broadcast on NTV television news. “In 2013, or at least by the end of this year, we will forget foot bindings. I’m asking you, please, if there is need we will provide additional funds. But we need to finally, fully reject this concept in our armed forces.”

It is hardly the stuff to alarm a Central Intelligence Agency military analyst. But it sheds light on the Russian military all the same.

NTV in Russia, reporting the change, noted that foot bindings were a common solution in militaries predating industrial looms, though “Russia is just about the only country where new enlisted men still learn to twirl portyanki.” (The video below gives a sense of what twirling looks like.)

The bindings are not unique to Russia. Such foot coverings were known as puttees when they had wide-scale use in the United States, Canadian and British militaries before and during World War I. Then, they were worn wrapped around the calf, above the boot.

(The video below shows another variety of these sock alternatives.)

In the Russian version, a swath of cloth about a foot wide, cotton in the summer, flannel in the winter, is inserted into the boot, effective against trench foot and frostbite alike, if bound correctly.

In basic training, even before breaking down a Kalashnikov, a Russian conscript learns to twist the portyanki around his feet to form mummylike cocoons, fit for the inside of the standard-issue Russian infantry boots, made today, as they were a century ago, of blackened canvas on a sole of rawhide. Running in these heavy boots, former soldiers say, is all but impossible.

This system of footwear had its principal advantage in military-industrial planning and logistics, freeing up Soviet factories from sewing millions of socks and allowing soldiers to tear wraps from old sheets in the field, if needed. During the Afghan war, however, Russian soldiers soured on the heavy boots; officers allowed soldiers to shed them for nonregulation running shoes.

The switch to socks began during the never-completed military reform in 2007, so some units march at parades in socks and lace-up boots, others in portyanki and boots without laces.

The minister’s statement on socks to the assembled generals may also have carried a deeper meaning, said Ruslan Pukhov, an analyst with the Center for Analysis of Strategies and Technologies. The cloth strips, almost a symbol of the Russian enlisted man’s life, are also emblematic of outmoded practices, he said.

Deeper changes, with higher stakes, are under way in the Russian military. Since 2007, the political leadership has systematically thinned the top-heavy officer ranks to alter the “egg-shaped” hierarchy of the army into a pyramid form. Mr. Shoigu’s order to complete the switch to socks, Mr. Pukhov said, signaled to the generals that they would not be exempt from following through with the reforms begun by his disgraced predecessor, Anatoly E. Serdyukov, who is under investigation for real estate deals involving the ministry’s property.

“We cannot fight the wars of the 21st century with the equipment we used 35 years ago in Afghanistan,” Mr. Pukhov said. “That is impossible to think about.”

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Wheels Blog: The Seventh-Generation Corvette Is Unveiled in Detroit

DETROIT — The Stingray is back, in name and in spirit.

At an invitation-only gathering hours before the North American International Auto Show was scheduled to open for press previews, General Motors introduced the 2014 Corvette, the seventh generation of Chevrolet’s hallmark sports car.

Underscoring the importance of this vehicle was Chevrolet’s revival of the long-dormant Stingray badge, a name it first used on a 1959 racecar built by G.M.’s design chief, Bill Mitchell. The hope for that original Stingray racecar was to beat Europe’s best, and G.M. still seems to be thinking along those lines.

According to G.M.’s president for North America, Mark Reuss, the latest Stingray is a potential worldbeater.

“Like the ’63 Sting Ray, the best Corvettes embodied performance leadership, delivering cutting-edge technologies, breathtaking design and awe-inspiring driving experiences,” Mr. Reuss said. “The all-new Corvette goes farther than ever, thanks to today’s advancements in design technology and engineering.”

The release of a new Corvette is always highly anticipated by auto enthusiasts; speculation about “C7″ — shorthand for the seventh generation — has run high. Would it get a twin-cam turbocharged powertrain? Would Chevy switch to an exotic midengine chassis?

In actuality, the 2014 model will again have a pushrod V-8 engine in its nose, driving the rear wheels. That conservative approach might be seen as a timid compromise from a company that has just begun to get back on solid financial footing. But the front-engine, rear-drive layout has long defined the Corvette, and this car, like its C6 predecessor, may well show its taillights to cars with specs that more closely conform to what is considered state of the art.

While automakers are quick to toss around the words “all new” to describe their latest offerings, however warmed over they might be, in this case the term is justified — the 2014 Corvette shares only two parts with its predecessor.

The C7 Corvette’s styling is in keeping with the brand’s persona, yet it projects a more aggressive image than previous generations. The clean front fascia is devoid of parking lights, and is energized by a sharp edge where it meets the hood, which is itself defined by a prominent bulge and more hard edges. The curve of the front fenders peaks at yet another edge that blends seamlessly into the body side at the A-pillar. The body’s flanks are defined by character lines that race back from vents behind the front wheel, not unlike those of previous Corvettes, but here those lines are more sharply drawn, with the upper line sweeping up and back to define the shape of the rear quarter panel. The lower character line projects from the body, forming a wing of sorts that flows out of the front fender and terminates at the rear of the door. The coupe’s roofline arcs smoothly to meet the rear spoiler, rather than terminating at the rear window, as in the C6. The individual rear taillights that have long been a part of Corvette design are now paired in a deep recess on each side. Four large exhaust pipes exit center-stage, rear.

The sheet-molded fiberglass body, with carbon-fiber hood and roof panels and carbon-nano composite underbody panels, is 37 pounds lighter than the C6’s body. It rides on a new aluminum frame that is 57 percent stiffer and 99 pounds lighter than the current model’s. The wheelbase is about one inch longer than that of the C6, and the track is almost an inch wider — changes said to provide a more stable feel at high speed.

Inside the cockpit, considerable effort was lavished on upgrading what has generally been considered a blighted zone. Optional carbon fiber trim and real aluminum combine with plastic in a wraparound configuration. The steering wheel, with a 14.1 inch diameter, is smaller than that of the previous model, and two seat choices are offered, with the competition sport version providing more side bolstering to hold occupants in place in spirited maneuvers. Indicative of the car’s purpose is the inclusion of a console-mounted steel grab bar for the passenger.

Under the hood, Chevrolet’s 6.2-liter small block V-8 — now in its fifth-generation design — produces an estimated 450 horsepower and 450 pound-feet of torque. At low speed, torque output exceeds that of the previous 6.2-liter engine by 50 pound-feet. The engine shares few parts with prior Corvette V-8s and is fitted with direct fuel injection that, in combination with other refinements, enables a high compression ratio of 11.5:1. Active Fuel Management, G.M.’s system for deactivating cylinders when they are not needed, lets the car cruise on four cylinders in some driving modes. Final fuel-economy numbers are not yet available.

Two transaxles will be offered: a 6-speed automatic with paddle-shift mode or a 7-speed manual with rev-matching capability — an electronic version of the heel-and-toe shifting techniques that competition drivers employ to enable smooth gear changes when negotiating twisty bits.

The Corvette driver will be able to select from among five driving modes: weather, Eco, Tour, Sport and Track; the default setting will be Tour. Changing modes alters 12 vehicle attributes, including throttle response, shift points, engagement of the limited-slip differential engagement, shock damping and more. Four-piston Brembo brakes provide stopping power, and electric power steering sets the course.

An optional Z51 performance package adds an electronic limited-slip differential that can continuously vary torque split between the rear wheels, dry-sump oiling, upgraded shock absorbers, a revised version of the automaker’s Magnetic Ride Control suspension-regulating system, close-ratio gears for the manual transmission, larger brake rotors and aerodynamic refinements that incorporate air-flow management for cooling of heat-stressed components.

Like its predecessor, the 2014 Corvette Stingray will be built at a G.M. plant in Bowling Green, Ky. The car is expected to arrive at dealerships in the third quarter of this year.

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